Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas

Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas

Blog Article

Abstract The microbiome is EYE SHADOW SHIMMERING NUDES #1505 fundamentally one of the most unique organs in the human body.Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events.We used a pan-pathogen array technology (PathoChip) coupled with next-generation sequencing to establish microbial signatures unique to human oral and oropharyngeal squamous cell carcinomas (OCSCC/OPSCC).

Signatures for DNA and RNA viruses including oncogenic viruses, gram positive and negative bacteria, fungi and parasites were detected.Cluster and topological analyses identified 2 distinct groups of microbial signatures related to OCSCCs/OPSCCs.Results were validated by probe ACETYL L-CARNITINE capture next generation sequencing; the data from which also provided a comprehensive map of integration sites and chromosomal hotspots for micro-organism genomic insertions.

Identification of these microbial signatures and their integration sites may provide biomarkers for OCSCC/OPSCC diagnosis and prognosis as well as novel avenues for study of their potential role in OCSCCs/OPSCCs.